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南安普顿大学
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脑并发症的患者首次全英国的研究与covid-19

发表: 2020年6月26日
新冠病毒

研究人员 from the dafabet888官网 are amongst a UK team of scientists to conduct the first nationwide surveillance study of the neurological complications of COVID-19.

A study of 153 patients treated in UK hospitals during the acute phase of the COVID-19 pandemic describes a range of neurological and psychiatric complications that may be linked to the disease, including stroke and an altered mental state such as brain inflammation, psychosis 和 dementia-like symptoms.

该研究结果发表在 柳叶刀精神病学 and provide valuable and timely information urgently needed by clinicians, researchers, and funders to inform the next steps in neuroscience COVID-19 research 和 health policy planning.

Increasingly, concerns regarding potential neurological complications of COVID-19 are being reported. However, most published reports have been limited to individual cases or small case series and even larger studies have been limited by both geography and specialty. Consequently, many important questions remain, such as how common complications are, whether novel syndromes are emerging, 和 which people are most at risk.

要解决这个问题, coronerve研究组, a collaboration between the universities of Liverpool, 南安普敦, Newcastle and UCL, developed a rapid notification case identification system across the spectrum of major UK Neuroscience Professional Bodies, representing neurology, stroke, psychiatry, 和 intensive care.

During three weeks of the exponential pandemic phase, the researchers identified 153 cases from across the UK who had both a new COVID-19 diagnosis and a new neurological or psychiatric diagnosis requiring hospital admission, including those admitted to intensive care 和/or recovering from critical illness.

The median age of the patients was 71 (23-94) years. Of the 125 patients for whom complete clinical data was available, 57 (44%) suffered ischemic strokes and 39 (31%) experienced an altered mental state reflecting both neurological 和 psychiatric diagnoses.

而61(82%)例脑血管事件发生于60岁以上,一半的情况下与精神状态改变是60岁以下。

南安普敦的研究小组,通过领导 博士aravinthan varatharaj伊恩博士帽状, 来自 南安普敦临床与实验神经学团队,用这个数据来调查因果关系和covid-19期间确定的神经受累的危险因素。

Dr Galea, Associate Professor 和 senior author leading the study for 南安普敦, said: “南安普顿大学 played a key role in establishing the UK-wide surveillance system CoroNerve to monitor serious effects of COVID-19 on the nervous system. The project continues with the next phase, during which the University’s world-leading 临床信息研究单位, are playing an essential role to help researchers identify risk factors for early identification of neurological involvement 和 effective treatment strategies.”

Dr Benedict Michael, who led the study for the University of Liverpool said: “Whilst an altered mental state was being reported by some clinicians, we were surprised to identify quite so many cases, particularly in younger patients, and by the breadth of clinical syndromes ranging from brain inflammation (encephalitis) through to psychosis 和 catatonia.

“Clinicians should be alert to the possibility of patients with COVID-19 developing these complications and, conversely, of the possibility of COVID-19 in patients presenting with acute neurological 和 psychiatric syndromes.”

It is not possible to draw conclusions about the total proportion of COVID-19 patients likely to be affected based on this study. Larger studies are now needed to identify the broader cohort of COVID-19 patients both in and outside of hospitals, to determine clearer estimates of the prevalence of these complications, those at risk, 和 impact on recovery.

Co-author Professor Tom Solomon, Director of the National Institute for Health Research Health Protection 研究 Unit in Emerging and Zoonotic Infections at the University of Liverpool said: “This study provides a great snapshot of the spectrum of COVID-19 associated neurological disease in the UK. Now we can recognise these problems, we need to understand in more detail why some patients are developing these complications, 和 what we can do to stop it. It will also be interesting to see how these data compare with other countries.”

The coronerve研究组 is supported by the Association of British Neurologists, Royal College of Psychiatrists, British Association of Stroke Physicians, British Paediatric Neurology Association, NeuroAnaesthesia and Critical Care Society, Intensive Care Society, Faculty of Intensive Care Medicine 和 the Encephalitis Society.

The researchers are supported by grants from the Medical Research Council, Wellcome, National Institute of Health 研究 和 Academy of Medical Sciences.

“153例covid-19的神经学和神经并发症:英国范围内的监测研究”发表在柳叶刀精神病学(//doi.org/10.1016/s2215-0366(20)30287-x)。

 

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